1. To observe the effect of polysaccharide of Lycium ruthenicum fruit on diabetes mellitus by intragastric administration of polysaccharide extract of Fructus Fructus Lycii fruit to normal mice, and then induce the diabetic mice by artificial method.
The results showed that the fruit polysaccharides of Lycium ruthenicum had the effect of preventing diabetes.
2. To observe the effect of polysaccharides from fruit of Lycium ruthenicum on diabetes mellitus by intragastric administration of polysaccharide extract of Fructus Lycii fruit. The results showed that the polysaccharides of Fructus Lycii fruit had significant hypoglycemic effect, but hypoglycemic effect was weaker than that of metformin hydrochloride.
3. The mechanism of the effect of polysaccharide of Fructus Lycii fruit on the level of SOD, MDA and glycogen was studied. SOD is an important enzyme that scavenges oxygen free radicals and directly reflects the antioxidant level of the body (the higher the value, the stronger the antioxidant capacity) MDA is the lipid peroxidation product caused by free radicals, which indirectly reflects the antioxidant capacity of the body Low, the stronger the oxidation resistance).
The results showed that the mechanism of polysaccharide deprivation of Lycium ruthenicum fruit is to decrease or prevent the injury of islet β cells by promoting the biosynthesis of antioxidant such as SO D, increasing the antioxidant capacity of the organism and scavenging oxidation products, Promote the repair and regeneration of islet β-cells.
4. The effects of fruit polysaccharide of Lycium ruthenicum fruit on body weight, food intake and water consumption of diabetic mice were observed. Diabetic patients eat more food, weight loss symptoms are very prominent.
Experiments show that: black fruit Lycium barbarum polysaccharides can reduce the amount of food and water consumption of diabetic mice, increase the weight of diabetic mice, this effect is helpful to alleviate the symptoms of diabetes, and metformin hydrochloride does not reduce the effect of diabetic mice food intake.
Diabetes is islet B cell damage or islet resistance, the former is a type of diabetes, which is type 2 diabetes, diabetes pathogenesis is not yet clear, clinical can not be cured.